RevivaCore Research Overview: Retatrutide
(Triple Receptor Power)
⚠ FOR RESEARCH PURPOSES ONLY
This document is provided solely for scientific and informational reference. RevivaCore does not promote or condone the use of any compounds for human consumption. All products are for laboratory research use only.
Quick Facts
Retatrutide (LY3437943) is a triple agonist that interacts with Glucagon, GIP, and GLP-1 receptors at the same time. This 'three-pathway' activity has drawn interest in research for its potential effects on fat metabolism, appetite regulation, and overall energy balance, going beyond what’s seen with single or dual agonists.
Glucagon receptor agonism – Explored for potential impact on energy use and fat metabolism
GIP agonism – Studied for its role in insulin signaling and lipid metabolism
GLP-1 agonism – Investigated for effects on appetite pathways, gastric emptying, and glucose regulation
Early findings suggest a potential muscle-sparing effect, helping maintain lean mass while supporting fat metabolism.
Researchers are actively exploring how it compares to other GLP-1 compounds in advanced metabolic studies.
Quick Reference:
What it is:
Retatrutide is a synthetic peptide that activates three receptors glucagon, GIP, and GLP‑1, and is being explored in preclinical and clinical research for its potential effects on glucose metabolism, energy expenditure, adipose regulation, and appetite control.
Key references:
Coskun et al., 2022 – Cell Metabolism (LY3437943 discovery to clinical proof of concept).
Jastreboff et al., 2023 – The New England Journal of Medicine (phase 2 clinical data in adults with obesity).
Handling & Storage
Before Reconstitution:
Store lyophilized powder in a cool, dry, dark environment; freeze for long‑term storage.
Avoid multiple freeze/thaw cycles to preserve integrity.
Reconstitution:
Recommended volume: 1–2 mL bacteriostatic water (BAC) for any vial size.
Use sterile technique in a clean research setting; minimize agitation.
Optional: 0.22 μm sterile filter to improve clarity and reduce particulates.
After Reconstitution:
Store between 2–8 °C (36–46 °F) in opaque/insulated storage to limit light exposure.
Avoid shaking or excessive movement; visually inspect prior to each draw and discard if cloudy or particulates are present.
Use within ~30 days if reconstituted with BAC water.
Common Lab Practices
Many research settings begin with lower microgram‑to‑milligram exposure levels over longer observation periods to monitor stability and subtle biological signals, rather than rapidly escalating to upper limits.
Community Support
Beginner-friendly support is available in our ThriveRoot ‘Peptides 101’ community.
Compliance Reminder
All RevivaCore compounds are for research and analytical use only. Not for human consumption. Buyer assumes all responsibility for lawful application within their jurisdiction.
If you have questions, contact us at support@revivacore.com
